Total synthesis of cyclotheonamide B, a facile route towards analogues

Article abstract of DOI:10.1016/00404-0399(50)11539-

A flexible, convergent synthesis of cyclotheonamide B (1b) was developed, starting from the constituent amino acids, using conventional benzyl-, t-butyl- and allyl-based protecting groups. By modification of the key intermediates, this approach allows the preparation of cyclotheonamide analogues.