Tetrahedron Letters p. 3051 - 3054 (1997)
Update date:2022-08-02
Topics:
Heaney, Harry
Taha, Mutasem O.
Slawin, Alexandra M. Z.
The oxidation of α-alkylhomophthalimide derivatives by dioxygen in the presence of ethanolic sodium hydroxide leads to the rapid formation of α-hydroxy-α-alkylhomophthalimide derivatives and hence, as a result of ring cleavage and lactone formation, to α-amido-α-alkylphthalides, potential precursors to phthalide isoquinoli ne alkaloids and analogues.
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