Hydroquinone-O,O'-diacetic acid as a more labile replacement for succinic acid linkers in solid-phase oligonucleotide synthesis

DOI: 10.1016/S0040-4039(97)00619-9

Source and publish data:

Tetrahedron Letters p. 3327 - 3330 (1997)

Update date:2022-08-05

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Authors:

Pon, Richard T.

Yu, Shuyuan

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Article abstract of DOI:10.1016/S0040-4039(97)00619-9

Hydroquinone-O,O'-diacetic acid (QDA) can be used to link nucleosides to CPG or polystyrene supports instead of succinic acid. Cleavage of oligodeoxy- or oligoribonucleotides, using ammonium hydroxide, requires only two to five minutes. The QDA linker is

Full text of DOI:10.1016/S0040-4039(97)00619-9

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