Hydroquinone-O,O'-diacetic acid as a more labile replacement for succinic acid linkers in solid-phase oligonucleotide synthesis

DOI: 10.1016/S0040-4039(97)00619-9

Source and publish data:

Tetrahedron Letters p. 3327 - 3330 (1997)

Update date:2022-08-05

Topics:

Authors:

Pon, Richard T.

Yu, Shuyuan

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)00619-9

Hydroquinone-O,O'-diacetic acid (QDA) can be used to link nucleosides to CPG or polystyrene supports instead of succinic acid. Cleavage of oligodeoxy- or oligoribonucleotides, using ammonium hydroxide, requires only two to five minutes. The QDA linker is

Full text of DOI:10.1016/S0040-4039(97)00619-9

Products guided by the article

Product name:Thymidine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-, 3'-[[4-(carboxymethoxy)phenoxy]acetate]

Cas No:190836-31-8

R&D Labs maybe for 190836-31-8

Hubei Onward Bio-Development Co., Ltd.

Contact:+86-718-8417012

Address:No.517,Shizhou Avenue,Enshi City,Hubei Province,China,445002
Liaoyang hengye Chemical Co., Ltd.

Contact:86-419-5850866

Address:North Old Xiaoxiao Road,Yantai District, Dengta, Liaoyang, Liaoning, China
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
Tractus Company Limited

Contact:+852-8198 2399

Address:9E, Leapont Industrial Building, 18-28 Wo Liu Hang Road, Shatin, New Territories, Hong Kong
Shandong Xingshun New Material Co., Ltd.

website:http://www.sd-xingshun.com

Contact:+86-519-86461196/+86-519-86464994

Address:Middle of Luhua East Road, Dingtao District

Relevant to this article

Chiral diphosphites derived from D-glucose: New ligands for the asymmetric catalytic hydroformylation of vinyl arenes

Doi:10.1002/1521-3765(20010716)7:14<3086::AID-CHEM3086>3.0.CO;2-O
(2001)
Structure-Elucidating Total Synthesis of the (Polyenoyl)tetramic Acid Militarinone C §

Doi:10.1021/acs.orglett.0c00431
(2020)
Cycloaromatization of a non-conjugated polyenyne system: Synthesis of 5H-benzo[d]fluoreno[3,2-b]pyrans via diradicals generated from 1-[2-{4-(2-alkoxymethylphenyl)butan-1,3-dinyl}]phenylpentan-2,4-diyn -1-ols and trapping evidence for the 1,2-didehydrobenzene diradical

Doi:10.1016/S0040-4039(97)00785-5
(1997)
Stereoselective synthesis of 2-deoxy-β-glycosides from glycal precursors. 2. Stereochemistry of glycosidation reactions of 2-thiophenyl- and 2-selenophenyl-α-D-gluco-pyranosyl donors

Doi:10.1016/S0040-4020(97)90395-1
(1997)
Immunogens from a synthetic hexasaccharide fragment of the O-SP of Vibrio cholerae O:1, serotype Ogawa

Doi:10.1016/j.tetasy.2004.11.021
(2005)
Palladium-Catalyzed Synthesis of Deuterated Alkenes through Deuterodechlorination of Alkenyl Chlorides

Doi:10.1021/acs.oprd.9b00193
(2019)

Article Doi