Bioorganic and Medicinal Chemistry Letters p. 1453 - 1458 (1999)
Update date:2022-08-04
Topics:
Duan, James J.-W
Chen, Lihua
Xue, Chu-Biao
Wasserman, Zelda R.
Hardman, Karl D.
Covington, Maryanne B.
Copeland, Robert R.
Arner, Elizabeth C.
Decicco, Carl P.
A novel series of 13- and 14-membered macrocyclic amines was developed by linking the P1 and P2' groups. The synthesis entails stereoselective Frater alkylation to install the anti-succinate configuration and macrocyclic amination via nucleophilic displacement. This strategy resulted in a new class of conformationally constrained inhibitors that are potent and selective for MMP-8 and 9 over MMP-1 and 3.
View MoreJiangsu Fengshan Group Co., Ltd.
Contact:86-25-86558671
Address:1903,Central International Mansion 105-6 North Zhongshan Road, Nanjing, China
website:http://www.chemdow.com
Contact:0086-10-82435335
Address:Room 401,Unit 3,4th Floor,Shangdijiayuan,Shangdi East Road, Haidian District,Beijing
Shijiazhuang Yunxuan Im&Export Co.,Ltd.
Contact:+86-311-83037514
Address:No.6 Hongbin Road
Luzhou North Chemical Co., Ltd.
Contact:+86-830-2796784;+86-830-2796776
Address:Gaoba, Longmatan District, Luzhou, Sichuan Province
A.M FOOD CHEMICAL CO., LIMITED
Contact:86-531-87100375
Address:20Floor,Bblock,1Building,pharma-valley,Jinan,China
Doi:10.1039/a607200c
(1997)Doi:10.1021/ja01588a037
(1956)Doi:10.1021/om970211l
(1997)Doi:10.1246/cl.1994.1013
(1994)Doi:10.1021/jo500061w
(2014)Doi:10.1021/ja00097a026
(1994)