Bioorganic and Medicinal Chemistry p. 4363 - 4374 (2018)
Update date:2022-07-30
Topics:
Zhang, Hao
Wang, Xuejian
Mao, Jing
Huang, Yongxue
Xu, Wenfang
Duan, Yu
Zhang, Jian
On the basis of the strategy of “multifunctional drugs”, a series of novel matrix metalloproteinase inhibitors (MMPIs) containing benzofuroxan scaffold as a nitric oxide donor were designed, synthesized and evaluated. All synthesized compounds, especially 16a, exhibited potent MMP-2,9 inhibitory activities, anti-proliferative activities and could produce high levels of NO in Hela cells. They were also evaluated for both of their anti-invasion and anti-angiogenesis effects. Furthermore, compared with LY52, 16a demonstrated competitive antitumor activity in vivo. These hybrid NO-MMPIs might offer suitable scaffolds to develop valuable MMP inhibitors for the further discovery of novel anti-cancer drugs.
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