Highly Stereoselective Introduction of Fluorine-Containing Methyl Groups at 2 Position of D-Glucose

Article abstract of DOI:10.1055/s-1997-3264

Highly stereoselective introduction of fluorine-containing methyl groups at the 2 position of methyl glucoside was attained by use of the difluoromethylene derivative as a key intermediate via hydrogenation of exo- and endo-olefins, whose diastereofacial selectivity was considered to be governed by the anomeric methoxy group.