Synthesis and cytotoxicity of amino analogues of the potent DNA alkylating agent seco-CBI-TMI

Article abstract of DOI:10.1016/S0960-894X(97)00259-X

The synthesis of racemic seco-CBI-TMI analogues containing nitrogen-based groups in place of the 5-OH is reported, employing a synthetic strategy where the incipient C-5 amino substituent is generated in the last step from a nitro precursor. The resulting