Bioorganic and Medicinal Chemistry Letters p. 81 - 86 (1996)
Update date:2022-08-05
Topics:
Sall, Daniel J.
Arfsten, Ann E.
Berry, Dennis R.
Denney, Michael L.
Harms, Cathy S.
McCowan, Jefferson R.
Ray, Judith K.
Scarborough, Robert M.
Um, Suzane L.
Utterback, Barbara G.
Jakubowski, Joseph A.
A series of substituted amidinoindoles have been prepared as mimics of the RGD sequence and were studied as antagonists of the platelet glycoprotein IIb-IIIa receptor (GPIIb-IIIa). The agents were potent and selective antagonists of GPIIb-IIIa. Compared to their acyclic counterparts, the amidinoindole series bound with 10- to 20-fold greater affinity, indicating the advantages of added conformational restriction and/or hydrophobicity in the basic region of RGD mimics.
View MoreDalian Join King Biochemical Tech. Co., Ltd.
Contact:0411 39216206
Address:814 First State Blvd
Jinan Hongfangde Pharmatech Co.,Ltd
Contact:86-531-88870908
Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
ChangZhou Mascotchem. Co.,Ltd.
website:http://www.mascotchem.com
Contact:86-519-85010339
Address:B-802,XingBei Building,391#,Tongjiang Middle Road New District,Changzhou,JS,China
Contact:+86-0512-88957371
Address:shanghai
Yurui(Shanghai)Chemical Co.,Ltd
Contact:0086 21-50456736
Address:No.3188 Xiupu Road,Shanghai
Doi:10.1016/j.tet.2013.03.071
(2013)Doi:10.1007/BF02495407
(1997)Doi:10.7164/antibiotics.50.586
(1997)Doi:10.1021/ja962465o
(1997)Doi:10.1021/jo971027c
(1997)Doi:10.1016/S0040-4039(97)01262-8
(1997)
