1β-methyl-2-(5-substituted pyrrolidin-3-ylthio)carbapenems; 2. Synthesis and antibacterial activity of 5-aminopropyl and 5-aminopropenyl pyrrolidine derivatives

Article abstract of DOI:10.7164/antibiotics.50.586

The synthesis and biological activity of (1R,5S,6S)-2-[(3S,5S)-5-substituted pyrrolidin-3-ylthio]-6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3 -carboxylic acid, in which aminopropyl, aminopropenyl, and aminopropynyl groups were introduced as substitu