
Tetrahedron p. 10743 - 10752 (1997)
Update date:2022-08-03
Topics:
Dauban, Philippe
Hofmann, Bernhard
Dodd, Robert H.
A formal synthesis of the novel (1S,4S,5R)-N-(benzyloxycarbonyl(-4-diethoxyphosphinyl)methyl-3-oxa-6 -azabicyclo[3.1.0]hexan-2-one 4 from D-ribose is presented. A key step involves the use of the 2,3-sulfate 12 for introduction of the C-3 azide functionality prior to aziridine ring formation.
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