Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide

DOI: 10.1016/S0040-4039(97)01215-X

Source and publish data:

Tetrahedron Letters p. 5433 - 5436 (1997)

Update date:2022-08-04

Topics:

Authors:

Schultz, Arthur G.

Pettus, Liping

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Article abstract of DOI:10.1016/S0040-4039(97)01215-X

Birch reduction-alkylation of the chiral 2-(trimethylsilyl)benzamide 4 provides 1,4-cyclohexadienes 5b-5e with diastereomer ratios of >100:1. The conversions of 5b-5e to the 4,4-disubstituted-2-cyclohexen-1-ones 8b-8e are described.

Full text of DOI:10.1016/S0040-4039(97)01215-X

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