Asymmetric synthesis of 4,4-disubstituted-2-cyclohexen-1-ones from a chiral 2-(trimethylsilyl)benzamide

DOI: 10.1016/S0040-4039(97)01215-X

Source and publish data:

Tetrahedron Letters p. 5433 - 5436 (1997)

Update date:2022-08-04

Topics:

Authors:

Schultz, Arthur G.

Pettus, Liping

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(97)01215-X

Birch reduction-alkylation of the chiral 2-(trimethylsilyl)benzamide 4 provides 1,4-cyclohexadienes 5b-5e with diastereomer ratios of >100:1. The conversions of 5b-5e to the 4,4-disubstituted-2-cyclohexen-1-ones 8b-8e are described.

Full text of DOI:10.1016/S0040-4039(97)01215-X

Products guided by the article

Product name:(R)-4-Isopropyl-4-((S)-2-methoxymethyl-pyrrolidine-1-carbonyl)-3-trimethylsilanyl-cyclohexa-2,5-dienone

Cas No:194656-48-9

R&D Labs maybe for 194656-48-9

Changsha Yihai Chemical Technology Co.,ltd

website:http://www.cs-yihai.com/

Contact:0731- 85620465

Address:Room 23005, unit 2, the northern building of Xiangsong international building , NO.259 Shaoshan Road , Changsha , Hunan, China.(mainland)
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
Shenyang Xinyihan Chemical Technology Co., Ltd.

Contact:+86-18525026267

Address:362, aigongbeijei street 23 , tiexi district,Shenyang, Liaoning, China
shijiazhuang baisheng chem co.; ltd

Contact:86-0311-80790826

Address:shijiazhuang hebei
Wuhan Chemwish Technology Co., Ltd

website:http://www.chemwish.com/

Contact:+86-27-67849912

Address:Room 1311, Unit 2, Block1, Innovation Road East Lake High-tech Development Zone Wuhan, Hubei，P.R. China

Relevant to this article

Stereoselective synthesis of the four stereoisomers of 4-(N,N- dibenzylamino)-2,2-dimethyl-3-hydroxypentanenitrile

Doi:10.1080/00397919708004183
(1997)
Synthesis of the new chiral (R)- and (S)-aminodiphosphine ligands sec-butylbis(2-(diphenylphosphino)ethyl)amine, sec-butylbis(2-(dicyclohexylphosphino)ethyl)amine, and (α-methylbenzyl)bis(2-(dicyclohexylphosphino)ethyl)amine and their organometallic chemistry when combined with iridium

Doi:10.1021/om9704455
(1997)
Anionic Homologous Fries Rearrangement of O-(2-Methylaryl)carbamates. A Regiospecific Route to Benzo[b]furan-2(3H)-ones including an Unnamed Metabolite from Helenium Species

Doi:10.1055/s-1997-5743
(1997)
Acid-promoted isomerization of a tungsten-η¹-2,5-dihydropyrrolyl complex to its tungsten-η¹-2,3-dihydropyrrolyl isomer

Doi:10.1021/om970563s
(1997)
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents

Doi:10.1021/jm010929+
(2001)
Effect of coordination dissymmetry on the catalytic activity of manganese catalase mimics

Doi:10.1016/j.jinorgbio.2020.111264
(2020)

Article Doi