Enantioselective total synthesis and structure determination of the mercapturic acid sulfoxide conjugate

DOI: 10.1016/S0960-894X(97)00363-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2033 - 2036 (1997)

Update date:2022-08-04

Topics:

Authors:

Nakamura, Shizuo

Goto, Kiyoto

Kondo, Mitsuyoshi

Naito, Shinsaku

Tsuda, Yoshiaki

Shishido, Kozo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(97)00363-6

A practical and enantioselective total synthesis of the mercapturic acid sulfoxide 4, a metabolite of anti-inflammatory drug DUP 697 1, has been accomplished by employing the substrate-controlled diastereoselective oxidation of the sulfide 7 to the sulfoxide 8 as the key step. This led to the structure determination of 4.

Full text of DOI:10.1016/S0960-894X(97)00363-6

Products guided by the article

Product name:(R)-2-Acetylamino-3-[5-(4-fluoro-phenyl)-4-(4-methanesulfonyl-phenyl)-thiophen-2-ylsulfanyl]-propionic acid 2-methoxy-ethoxymethyl ester

Cas No:195704-96-2

R&D Labs maybe for 195704-96-2

Zhejiang Chemicals Import & Export Corporation

Contact:86-571-87043088

Address:No.37,Qingchun Road,Hangzhou,China
Nantong Baokai Chemical Co., Ltd (Hangzhou Baokai Bio-Chemicals Co.,Ltd.)

Contact:+86-513-83886111

Address:No. 68 Suzhou road ,Binjiang Fine Chemical Industrial Park , Beixin town, Qidong city ,Jiangsu province
Beijing Cooperate Pharmaceutical Co.,Ltd

website:http://www.cooperate-pharm.com/

Contact:86-01060279497

Address:No.507,Building 4,Tianhua Street, Biomedicine industrial Base
shijiazhuang baisheng chem co.; ltd

Contact:86-0311-80790826

Address:shijiazhuang hebei
JIANGXI ZHANGFENG CHEMICAL CO., LTD.

Contact:+86-0799-3413066

Address:Xiyuan village, Xiabu Town, Xiangdong District

Relevant to this article

Doi:10.1007/BF00908457
()
Reaction chemistry of tri-substituted mesitylene derivatives and the synthesis of sterically buttressed 1,3,5-triaminocyclohexyl ligands

Doi:10.1039/a701364g
(1997)
Synthesis of pyrimido[5″,4″:5′,6′]pyrido[2′,3′:4,5]- thieno[2,3-c]pyridazine and pyridazino[4′3′:4,5]-thieno[3,2-b][1,8]naphthyridine, new tetrahete-rocyclic ring systems

Doi:10.3987/com-97-7865
(1997)
Doi:10.1021/jo01050a518
(1962)
Design, synthesis, antibacterial, and QSAR studies of myristic acid derivatives

Doi:10.1016/j.bmcl.2006.02.056
(2006)
Synthetic MUC1 antitumor vaccine with incorporated 2,3-sialyl-T carbohydrate antigen inducing strong immune responses with isotype specificity

Doi:10.1002/cbic.201800148
(2018)

Article Doi