Enantioselective total synthesis and structure determination of the mercapturic acid sulfoxide conjugate

DOI: 10.1016/S0960-894X(97)00363-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2033 - 2036 (1997)

Update date:2022-08-04

Topics:

Authors:

Nakamura, Shizuo

Goto, Kiyoto

Kondo, Mitsuyoshi

Naito, Shinsaku

Tsuda, Yoshiaki

Shishido, Kozo

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Article abstract of DOI:10.1016/S0960-894X(97)00363-6

A practical and enantioselective total synthesis of the mercapturic acid sulfoxide 4, a metabolite of anti-inflammatory drug DUP 697 1, has been accomplished by employing the substrate-controlled diastereoselective oxidation of the sulfide 7 to the sulfoxide 8 as the key step. This led to the structure determination of 4.

Full text of DOI:10.1016/S0960-894X(97)00363-6

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