Tetrahedron Letters p. 7175 - 7178 (1999)
Update date:2022-08-02
Topics:
Wittenberger, Steven J.
McLaughlin, Maureen A.
An enantioselective synthesis of ABT-627 is described. The key transformation is a diastereoselective 6-endo-trig cyclization to produce a 3,4,5-trisubstituted-1,2-oxazine which is ring contracted to the 2,3,4-tri-substituted-pyrrolidine core of ABT-627.
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