Preparation of endothelin antagonist ABT-627

DOI: 10.1016/S0040-4039(99)01497-5

Source and publish data:

Tetrahedron Letters p. 7175 - 7178 (1999)

Update date:2022-08-02

Topics:

Authors:

Wittenberger, Steven J.

McLaughlin, Maureen A.

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Article abstract of DOI:10.1016/S0040-4039(99)01497-5

An enantioselective synthesis of ABT-627 is described. The key transformation is a diastereoselective 6-endo-trig cyclization to produce a 3,4,5-trisubstituted-1,2-oxazine which is ring contracted to the 2,3,4-tri-substituted-pyrrolidine core of ABT-627.

Full text of DOI:10.1016/S0040-4039(99)01497-5

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