Chemical and Pharmaceutical Bulletin p. 1470 - 1474 (1997)
Update date:2022-08-02
Topics:
Kumazawa, Eiji
Hirotani, Kenji
Burford, S. Clifford
Kawagoe, Keiichi
Miwa, Tamotsu
Mitsui, Ikuo
Ejima, Akio
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.
View MoreShanggao Ruiya Fine Chemicals Co., Ltd
Contact:+86-795-2592103
Address:Xingguang Nanlu,Shanggao County Industry Park
website:http://www.alwaychem.com
Contact:+86-532-8586-4000, 8586-5000
Address:NO.51, TAIPING ROAD, QINGDAO, CHINA. 266001
Shanghai ZaiQi Bio-Tech Co., Ltd.,
Contact:+86-21-5482 4098
Address:Bldg. No.7, No.201 MinYi Rd，Songjiang CaoHeJing High-Tech Park Shanghai 201516 P,R,China
ZHIJIANG ZENVA SINO COMMERCE AND TRADE CO., LTD.
website:http://www.zenvasino.com
Contact:+86-138-72658998
Address:Shibeishan Road,Zhijiang, Hubei, China
Shandong Xinke Petrochemical Co., Ltd.
Contact:+86-546-7277016
Address:Gudao Industrial Park, Hekou District, Dongying, Shandong Province, China
Doi:10.1016/S0040-4020(97)00874-0
(1997)Doi:10.1016/j.bmcl.2010.07.139
(2010)Doi:10.1080/07328319708006130
(1997)Doi:10.1021/acs.orglett.5b01003
(2015)Doi:10.1021/ja01014a079
(1968)Doi:10.1016/j.tet.2006.02.080
(2006)
