Chemical and Pharmaceutical Bulletin p. 1470 - 1474 (1997)
Update date:2022-08-02
Topics:
Kumazawa, Eiji
Hirotani, Kenji
Burford, S. Clifford
Kawagoe, Keiichi
Miwa, Tamotsu
Mitsui, Ikuo
Ejima, Akio
Novel benzophenone derivatives were synthesized and screened for cytotoxic and antitumor activity. Friedel-Crafts condensation was employed to construct the benzophenone skeleton. Among the compounds synthesized, morpholino and thiomorpholino benzophenones 3a-d exhibited potent cytotoxic activity against P388 murine leukemia and PC-6 human lung carcinoma cells in vitro, and compounds 3a, 3c, and 3j, when administered intraperitoneally, showed significant antitumor activity against the malignant ascites caused by intraperitoneal inoculation of P388 cells in mice.
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