Structure-based design of non-peptidic pyridone aldehydes as inhibitors of interleukin-1β converting enzyme.

DOI: 10.1016/S0960-894X(97)00394-6

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2181 - 2186 (1997)

Update date:2022-08-05

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Authors:

Golec, Julian M. C.

Mullican, Michael D.

Murcko, Mark A.

Wilson, Keith P.

Kay, David P.

Jones, Stuart D.

Murdoch, Robert

Bemis, Guy W.

Raybuck, Scott A.

Luong, Yu-Ping

Livingston, David J.

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Article abstract of DOI:10.1016/S0960-894X(97)00394-6

Pyridone derivatives, especially with 6-aryl substituents, have been shown to be useful P₂-P₃ peptidomimetic scaffolds for the design of potent inhibitors of ICE.

Full text of DOI:10.1016/S0960-894X(97)00394-6

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Product name:2-(6-Benzyl-3-benzyloxycarbonylamino-2-oxo-2H-pyridin-1-yl)-propionic acid methyl ester

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