Studies on the total synthesis of the macrolide antitumor agent rhizoxin. 2. Synthesis of the C14-C26 segment

DOI: 10.1016/S0040-4039(97)01781-4

Source and publish data:

Tetrahedron Letters p. 7333 - 7336 (1997)

Update date:2022-08-05

Topics:

Authors:

White, James D.

Holoboski, Mark A.

Green, Neal J.

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Article abstract of DOI:10.1016/S0040-4039(97)01781-4

An asymmetric synthesis of the C14-C26 segment of rhizoxin is described in which the three stereogenic centers are derived from a γ-lactone; stannylcupration-methylation of a terminal alkyne is used to generate an (E)-iodoalkene for Stille coupling with a dienylstannane that produces the conjugated (E,E,E)-triene unit of rhizoxin.

Full text of DOI:10.1016/S0040-4039(97)01781-4

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