Tetrahedron Letters p. 8001 - 8004 (1997)
Update date:2022-07-30
Topics:
Eberle, Martin
Ghorai, Alex
Lawton, Richard G.
Reaction of Meldrum's acid, thiophenol and gluteraldehyde in aqueous acetonitrile with piperidine acetate affords a 70% yield of isopropylidene cis-2-hydroxy-6-phenylthiocyclohexane-1,1-dicarboxylate. The reaction is very general. It can be applied to dialdehydes derived in a many ways using many different thiols.
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