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458-37-7

Basic Information
CAS No.: 458-37-7
Name: 1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-
Molecular Structure:
Molecular Structure of 458-37-7 (1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-, (1E,6E)-)
Formula: C21H20O6
Molecular Weight: 368.39
Synonyms: 1,6-Heptadiene-3,5-dione,1,7-bis(4-hydroxy-3-methoxyphenyl)-, (E,E)- (8CI);Curcumin (6CI);(1E,6E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;(E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;(E,E)-1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione;C Yellow 15;C.I. 75300;C.I. Natural Yellow 3;Curcuma;Curcumin I;Diferuloylmethane;E 100;E 100 (dye);Halud;IndianSaffron;Kacha Haldi;Merita Earth;NSC 32982;San-Ei Curcumine AL;San-Ei Gen Curcumine AL;Terra Merita;Turmeric;Turmeric yellow;Ukon (dye);Yellow Ginger;trans,trans-Curcumin;Curcumin;
EINECS: 207-280-5
Density: 1.279 g/cm3
Melting Point: 183 °C
Boiling Point: 591.4 °C at 760 mmHg
Flash Point: 208.9 °C
Solubility: slightly soluble in hot water
Appearance: orange crystalline powder
Hazard Symbols: IrritantXi
Risk Codes: 36/37/38
Safety: 26-36
Transport Information:
PSA: 96.22000
LogP: 3.85260
Synthetic route
121-33-5

vanillin

123-54-6

acetylacetone

458-37-7

curcumin

Conditions
ConditionsYield
Stage #1: vanillin; acetylacetone With boron trioxide; boric acid tributyl ester In ethyl acetate for 0.333333h;
Stage #2: With N-butylamine In ethyl acetate at 80℃; for 15h;
93%
Stage #1: vanillin; acetylacetone With boron trioxide; boric acid tributyl ester In ethyl acetate at 50℃; for 0.166667h;
Stage #2: With N-butylamine In ethyl acetate at 50 - 80℃; for 4.25h;
85%
Stage #1: vanillin; acetylacetone With boron trioxide; boric acid tributyl ester In ethyl acetate at 50℃; for 0.0833333h; Aldol condensation; Inert atmosphere;
Stage #2: With N-butylamine In ethyl acetate at 50 - 80℃; for 4.25h; Inert atmosphere;
Stage #3: With hydrogenchloride In water; ethyl acetate for 0.5h; Inert atmosphere;
81%
121-33-5

vanillin

123-54-6

acetylacetone

A

458-37-7

curcumin

B

1924-25-0

4-hydroxy-6-(4-hydroxy-3-methoxyphenyl)3,5-hexadien-2-one

Conditions
ConditionsYield
With piperidine; triethyl borate; boron trioxide In 1,4-dioxaneA 8%
B 22%
626-96-0

4-oxopentanal

121-33-5

vanillin

A

458-37-7

curcumin

B

(1E,6E)-4-(4-hydroxy-3-methoxybenzylidene)-1,7-bis(4-hydroxy-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Conditions
ConditionsYield
With boron trioxide
112494-43-6

(1ξ)-1-hydroxy-1,7-bis(4-hydroxy-3-methoxyphenyl)-6-heptene-3,5-dione

458-37-7

curcumin

Conditions
ConditionsYield
at 130℃; under 15 Torr; for 10h;
123-08-0

4-hydroxy-benzaldehyde

121-33-5

vanillin

123-54-6

acetylacetone

A

458-37-7

curcumin

Conditions
ConditionsYield
With boric acid tributyl ester; boric acid In ethyl acetate at 40℃; for 0.5h;A 2.1 g
B 0.7 g
C 2.6 g
123-08-0

4-hydroxy-benzaldehyde

123-54-6

acetylacetone

A

458-37-7

curcumin

Conditions
ConditionsYield
With boric acid tributyl ester; boric acid; vanillin In ethyl acetate at 40℃; for 0.5h;A 2.1 g
B 0.7 g
C 2.6 g
121-33-5

vanillin

123-54-6

acetylacetone

A

458-37-7

curcumin

Conditions
ConditionsYield
With boric acid tributyl ester; boric acid; 4-hydroxy-benzaldehyde In ethyl acetate at 40℃; for 0.5h;A 2.1 g
B 0.7 g
C 2.6 g

1,7-bis-(3-methoxy-4-methoxycarbonyloxy-phenyl)-hepta-1,6-diene-3,5-dione

67-64-1

acetone

KOH-solution

KOH-solution

458-37-7

curcumin

1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; curcumin-tris hydrobromide

A

458-37-7

curcumin

B

10035-10-6, 12258-64-9

hydrogen bromide

Conditions
ConditionsYield
an trockner Luft;

1,7-bis-(4-hydroxy-3-methoxy-phenyl)-hepta-1,6-diene-3,5-dione; curcumin-tris hydrobromide

A

458-37-7

curcumin

B

10035-10-6, 12258-64-9

hydrogen bromide

curcumin phenoxyl radical

458-37-7

curcumin

Conditions
ConditionsYield
With ascorbic acid In water; dimethyl sulfoxide Kinetics;

curcumin radical cation

458-37-7

curcumin

Conditions
ConditionsYield
With triethylamine In various solvent(s) at 20℃; Kinetics;
121-33-5

vanillin

458-37-7

curcumin

Conditions
ConditionsYield
Stage #1: acetylacetone With boron trioxide In ethyl acetate at 20℃; for 1h;
Stage #2: vanillin With boric acid tributyl ester for 1h;
Stage #3: With N-butylamine In ethyl acetate for 48h;
100-52-7

benzaldehyde

123-54-6

acetylacetone

458-37-7

curcumin

Conditions
ConditionsYield
With boron trioxide
121-33-5

vanillin

acetylacetone-boric oxide complex

458-37-7

curcumin

Conditions
ConditionsYield
With tri-sec-butylborate; N-butylamine In ethyl acetate
54030-32-9

4-hydroxy-3-(hydroxymethyl)benzaldehyde

123-54-6

acetylacetone

458-37-7

curcumin

Conditions
ConditionsYield
Stage #1: 4-hydroxy-3-(hydroxymethyl)benzaldehyde; acetylacetone With boron trioxide; 1,2,3,4-tetrahydroisoquinoline In acetic acid at 110℃; for 24h;
Stage #2: In water; acetic acid at 20℃; for 24h;
524-14-1

S-(hydrogen malonyl)coenzyme A

458-37-7

curcumin

Conditions
ConditionsYield
With fusion protein of diketide-CoA synthase and curcumin synthase In aq. phosphate buffer at 37℃; for 8h; pH=7.5; Enzymatic reaction;
524-14-1

S-(hydrogen malonyl)coenzyme A

A

1080-12-2, 22214-42-2

(E)-4-(4-hydroxy-3-methoxyphenyl)but-3-ene-2-one

B

458-37-7

curcumin

Conditions
ConditionsYield
With curcumin synthase; diketide-CoA synthase In aq. phosphate buffer at 37℃; for 8h; pH=7.5; Enzymatic reaction;

C21H19O6(1-)

458-37-7

curcumin

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1.1: N,N-dimethyl-formamide / 12 h / 20 °C / Darkness
1.2: 5 h / 20 °C / Inert atmosphere; Darkness
2.1: dimethyl sulfoxide; water / 1 h / pH 7.2 / Irradiation
View Scheme

C21H25N2O6Pt(1+)*NO3(1-)

458-37-7

curcumin

Conditions
ConditionsYield
In water; dimethyl sulfoxide for 1h; pH=7.2; Irradiation;

C23H27N2O6Pt(1+)*NO3(1-)

458-37-7

curcumin

Conditions
ConditionsYield
In water; dimethyl sulfoxide for 1h; pH=7.2; Irradiation;

C27H33N2O6Pt(1+)*NO3(1-)

458-37-7

curcumin

Conditions
ConditionsYield
In water; dimethyl sulfoxide for 1h; pH=7.2; Irradiation;

rubrocurcumin

458-37-7

curcumin

Conditions
ConditionsYield
With water In acetone at 50℃; Kinetics;

C24H21BO10

458-37-7

curcumin

Conditions
ConditionsYield
With water In acetone at 50℃; Kinetics;

C28H23BO9

458-37-7

curcumin

Conditions
ConditionsYield
With water In acetone at 50℃; Kinetics;

C27H25BO13

458-37-7

curcumin

Conditions
ConditionsYield
With water In acetone at 50℃; Kinetics;

rosacyanine

458-37-7

curcumin

Conditions
ConditionsYield
With ethanol In N,N-dimethyl acetamide Solvent;
458-37-7

curcumin

108-24-7

acetic anhydride

297179-80-7

1,7-bis(4-acetoxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione

Conditions
ConditionsYield
With pyridine In 2-methyltetrahydrofuran for 2h; Reflux;98%
With sodium acetate
With pyridine In dichloromethane for 2h; Reflux;
458-37-7

curcumin

108-24-7

acetic anhydride

19697-86-0

((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-4,1-phenylene)diacetate

Conditions
ConditionsYield
With pyridine In dichloromethane for 2h; Reflux;98%
With sodium hydrogencarbonate; sodium carbonate; potassium hydrogencarbonate; acetyl chloride In dichloromethane; toluene; acetonitrile at 0℃; for 20h; Reagent/catalyst; Temperature; Solvent; Inert atmosphere;96%
With pyridine In dichloromethane for 1h; Reflux;95%
458-37-7

curcumin

99-61-6

3-nitro-benzaldehyde

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0583333h; Microwave irradiation; Green chemistry;98%
With piperidine In methanol at 60 - 65℃; for 20h;72%
458-37-7

curcumin

17356-08-0

thiourea

139-85-5

3,4-dihydroxybenzaldehyde

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(3,4-dihydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;98%
458-37-7

curcumin

95-54-5

1,2-diamino-benzene

4,4'-((1E,1'E)-(3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethene-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;97.5%
458-37-7

curcumin

100-52-7

benzaldehyde

1373886-08-8

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-phenyl-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With tin(II) chloride dihdyrate at 80℃; for 1.33333h; Neat (no solvent);97%
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.33333h; Green chemistry;97%
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;97%
With piperidine In methanol at 60 - 65℃; for 16h;76%
458-37-7

curcumin

90-02-8

salicylaldehyde

1373886-13-5

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(2-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;97%
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);96%
With piperidine In methanol at 60 - 65℃; for 18h;75%
458-37-7

curcumin

17356-08-0

thiourea

100-10-7

4-dimethylamino-benzaldehyde

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-N,N-dimethylphenyl)-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;97%
With piperidine In methanol at 60 - 65℃; for 16h;80%
458-37-7

curcumin

99-61-6

3-nitro-benzaldehyde

17356-08-0

thiourea

5-(4-hydroxy-3-methoxyphenylethylene carbonyl)-6-(4-hydroxy,3-methoxyphenylethylene)-4-(3-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;97%
458-37-7

curcumin

95-83-0

4-Chloro-1,2-phenylenediamine

4,4'-((1E,1'E)-(7-chloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethene-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;96.1%
458-37-7

curcumin

104-88-1

4-chlorobenzaldehyde

17356-08-0

thiourea

1373886-17-9

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With tin(II) chloride dihdyrate at 80℃; for 1.33333h; Neat (no solvent);96%
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;96%
458-37-7

curcumin

104-88-1

4-chlorobenzaldehyde

1373886-09-9

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-chlorophenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;96%
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.5h; Green chemistry;95%
With tin(II) chloride dihdyrate at 80℃; for 1.33333h; Neat (no solvent);94%
458-37-7

curcumin

555-16-8

4-nitrobenzaldehdye

1373886-10-2

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-nitrophenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);96%
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.33333h; Green chemistry;95%
458-37-7

curcumin

123-08-0

4-hydroxy-benzaldehyde

1373886-14-6

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.33333h; Green chemistry;96%
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;96%
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);95%
With piperidine In methanol at 60 - 65℃; for 18h;62%
458-37-7

curcumin

121-33-5

vanillin

17356-08-0

thiourea

1373886-20-4

C30H28N2O7S

Conditions
ConditionsYield
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.33333h; Green chemistry;96%
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);93%
458-37-7

curcumin

100-83-4

meta-hydroxybenzaldehyde

17356-08-0

thiourea

C29H26N2O6S

Conditions
ConditionsYield
With D-(+)-glucosamine hydrochloride In neat (no solvent) Microwave irradiation;96%
458-37-7

curcumin

106-95-6

allyl bromide

(1E,6E)-4,4-diallyl-1,7-bis(4-(allyloxy)-3-methoxyphenyl)hepta-1,6-diene-3,5-dione

Conditions
ConditionsYield
With [benzene-1,3,5-triyltris(methylene)]tris(triphenylphosphonium) tribromide; sodium hydroxide In dichloromethane; water at 30℃; for 12h;96%
458-37-7

curcumin

139-85-5

3,4-dihydroxybenzaldehyde

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(3,4-dihydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;96%
5348-42-5

4,5-Dichloro-1,2-phenylenediamine

458-37-7

curcumin

4,4'-((1E,1'E)-(7,8-dichloro-3H-benzo[b]-[1,4]-diazepine-2,4-diyl)bis(ethene-2,1-diyl))bis-(2-methoxyphenol)

Conditions
ConditionsYield
With sulfuric acid In ethanol at 20℃;95.3%
458-37-7

curcumin

7166-19-0, 18315-81-6, 39674-40-3

(2-bromo-2-nitroethenyl)benzene

(2E)-1-(2-(3-hydroxy-4-methoxystyryl)-4,5-dihydro-5-nitro-4-phenylfuran-3-yl)-3-(3-hydroxy-4-methoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With water; potassium carbonate In tetrahydrofuran at 20℃; for 2h; Feist-Benary reaction; Combinatorial reaction / High throughput screening (HTS); diastereoselective reaction;95%
14794-31-1

ethyl 3-(chloroformyl)propionate

458-37-7

curcumin

4,4'-((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-1,4-phenylene) diethyl disuccinate

Conditions
ConditionsYield
With dmap In dichloromethane at 20℃; for 2h; Inert atmosphere;95%
458-37-7

curcumin

100-52-7

benzaldehyde

17356-08-0

thiourea

1373886-16-8

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-phenyl-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With tin(II) chloride dihdyrate at 80℃; for 1.33333h; Neat (no solvent);95%
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;95%
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.33333h; Green chemistry;94%
With piperidine In methanol at 60 - 65℃; for 16h;76%
458-37-7

curcumin

123-08-0

4-hydroxy-benzaldehyde

17356-08-0

thiourea

1373886-21-5

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-hydroxyphenyl)-3,4-dihydropyrimidin-2(1H)-thione

Conditions
ConditionsYield
With phosphomolybdic acid In ethanol for 0.0416667h; Microwave irradiation; Green chemistry;95%
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);93%
458-37-7

curcumin

90-02-8

salicylaldehyde

17356-08-0

thiourea

C29H26N2O6S

Conditions
ConditionsYield
With D-(+)-glucosamine hydrochloride In neat (no solvent) Microwave irradiation;95%
458-37-7

curcumin

95-01-2

2,4-Dihydroxybenzaldehyde

C29H26N2O8

Conditions
ConditionsYield
With D-(+)-glucosamine hydrochloride In neat (no solvent) Microwave irradiation;95%
458-37-7

curcumin

17201-43-3

4-cyanobenzyl bromide

C53H40N4O6

Conditions
ConditionsYield
With [benzene-1,3,5-triyltris(methylene)]tris(triphenylphosphonium) tribromide; sodium hydroxide In dichloromethane; water at 30℃; for 12h;95%
458-37-7

curcumin

2826-24-6

4-bromobenzylidenemalononitrile

C30H25BrN2O6

Conditions
ConditionsYield
With piperidine; dmap In ethanol for 12h; Reflux;95%
458-37-7

curcumin

109-63-7

boron trifluoride diethyl etherate

2,2-difluoro-4,6-bis[β-(4-hydroxy-3-methoxystyryl)]-1,3,2-dioxaborine

Conditions
ConditionsYield
In dichloromethane at 20℃;95%
In tetrahydrofuran Reflux; Inert atmosphere;79%
In dichloromethane for 2h; Inert atmosphere; Reflux;510 mg
With acetic acid at 20℃; for 0.5h; Darkness;
In acetic acid at 20℃; for 0.5h; Sonication; Darkness;
458-37-7

curcumin

64-19-7

acetic acid

19697-86-0

((1E,6E)-3,5-dioxohepta-1,6-diene-1,7-diyl)bis(2-methoxy-4,1-phenylene)diacetate

Conditions
ConditionsYield
With pyridine In dichloromethane at 155℃; for 1h;95%
458-37-7

curcumin

104-87-0

4-methyl-benzaldehyde

1373886-15-7

5-(4-hydroxy-3-methoxyphenylethylenecarbonyl)-6-(4-hydroxy-3-methoxyphenylethylene)-4-(4-methylphenyl)-3,4-dihydropyrimidin-2(1H)-one

Conditions
ConditionsYield
With chitosan (viscosity 800–2000 cps) In water; acetic acid at 60℃; for 1.5h; Green chemistry;94%
With tin(II) chloride dihdyrate at 80℃; for 1.5h; Neat (no solvent);92%
With piperidine In methanol at 60 - 65℃; for 16h;81%
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    Business Type:Trading Company

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    Business Type:Lab/Research institutions

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    Business Type:Trading Company

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-571-88938639

    Address:9/F, Unit 2 Changdi Torch Building, 259# WenSan Road, Xihu District, Hangzhou City 310012, P.R.China

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-571-86465881,86-571-87157530,86-571-88025800

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    458-37-7

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    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional JIT service with instant market intelligence in China to benefit our

    Welcome to Simagchem, your partner in China as a premier supply of bulk specialty chemicals for industry and life science. We introduce experienced quality product and exceptional

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-592-2680277

    Address:21/F Hualong Office Building,No.6 Hubin East Road, Xiamen,China

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    458-37-7

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    Curcuma is a rhizomatous herbaceous perennial plant of the ginger family,Zingiberaceae. The active ingredient of curcuma extract is curcumin. Curcuma extract curcumin powder is commonly used as a spice in Indian and Chinese systems of medicine. C

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:86-29-86107037-8015

    Address:No.11 Daqing Road,Lianhu District,Xi’an 710082,China

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    458-37-7

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    Jinlan Pharm-Drugs Technology Co.,Limited (with its export company Hangzhou Royall Import & Export Co.,Ltd.)is located in Hangzhou, Zhejiang Province. Neighboring Ningbo port, Shanghai port, Hangzhou Xiaoshan Int’l Airport and Shanghai Pu

    Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd (JL Pharm) is established in 2012 at the beautiful West Lake – Hangzhou city, China. The company's main business includes R&D, Produ

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-571-85829053

    Address:Rm A606, Fuyi Center, jianqiao street, Jianggan Area

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    Mulei (Wuhan) New Material Technology Co. Ltd is a scientific and technological company integrating product research and development, manufacture and trading of chemical intermedia

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+8619831967063

    Address:Office1201#, Block C, Hanjie Headquarters International Plaza, Zhongbei Rd, Wuchang District, Wuhan

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    458-37-7

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    Xi'an Harmonious Natural Bio-Technology Co., Ltd. was founded in 2010, and located in Xian International Logistics Industrial Zone, Xi'an City, Shaanxi Province, China. Now it is

  •  Xi'an Harmonious Natural Bio-Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-029-86712509

    Address:huilinhuacheng 10-2104

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    458-37-7

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    Product Description: Curcumin CAS 458-37-7 is a saffron yellow and claybank powder. It is insoluble in water but soluble in organic solvents. The stable chemical property enables itself to tolerate high temperature and high pressure in the pr

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     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel:+86-551-65418695

    Address:B911 Xincheng Business Center, Qianshan Road, Hefei Anhui China

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    458-37-7

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    Our main production base is located in Xuzhou industry park. We produce a wide range of organics including Fine chemicals, Active pharmaceutical ingredients(APIs), Veterinary, In

  •  Chemwill Asia Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:021-51086038

    Address:High-Tech Industrial park,Chemical Economical Development Zone,Xuzhou, Jiangsu-Province, P.R.China

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    Shaanxi greenyo biotech co., ltd is one specialized company which engaged in the naturalplant extracts, pharmaceutical intermediates, chemical raw materials research and developmen

  •  Shaanxi Greenyo Biotech Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-29-81772657

    Address:Gaoxin 4th road, High-tech zone,

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    458-37-7

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    Founded in 2011, Amadis Chemical Company Limited is an innovative manufacturer of chemical products and technical service providers. Our business includes sales, manufacture, and s

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:86-571-89925085

    Address:Watts Cosine.No.166.Xiangmao Road.

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    458-37-7

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-29-86719484

    Address:B-1604,Juncheng Guoji, Taiyuan Road, Weiyang distirct

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    458-37-7

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    Business Type:Trading Company

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    High quality 99% Curcumin powder with good price TAIHO Unique Advantages: 1.We're factory 2.Free samples available 3.Commodity inspection can be done 4.ISO9001,Kosher certifications 5.10 years experiences Storage:Store in cool &dry place Packag

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  •  Hubei Taiho Chemical Co.,LTD

     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-18120399543

    Address:No. 49 taifeng Road,Qianjiang City,Hubei,China

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    458-37-7

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    Enbridge PharmTech Co., Ltd. is an innovative company integrated with R&D, manufacturing, marketing and distribution of intermediates and fine chemicals, mainly used to pharmaceuti

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:+86-510-83591909

    Address:Huishan Zone, Wuxi City, Jiangsu Province, P.R.China

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    458-37-7

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    The company was established in August 2014. It is a modern advanced enterprise specializing in the research and production of API, natural plant extracts and active cosmetic ingredients. The headquartered of the company is in the suburbs of Xi'a

    The company was established in August 2014. It is a modern and advanced enterprise specializing in the research and production of natural plant extracts and active cosmetic ingredi

  •  Shaanxi Yuantai Biological Technology Co., Ltd.

     China (Mainland)  |  Contact Details

    Business Type:Trading Company

    Tel::+86-029-86478251 Fax:+86-029-86119593

    Address:Shaanxi Province, Xi'an,Fengcheng road 4,Zhongdeng city garden, building 5,

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    458-37-7

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    Product name:Pure Curcumin Appearance: Orange-yellow powder Assay: 95% Part used:Root of Turmeric Test method:HPLC Packaging: 1kg/bag,25kg/drum Curcumin has antioxidant, anti-inflammatory, antiviral and antifungal actions. Studies have sh

    Welcome to Henan Sinotech! Sinotech Corporation has exceptional sourcing ability for chemicals used in Organic Fine Chemicals and APIs; Inorganic chemicals; Flame Retardants;OLED

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    Business Type:Other

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    458-37-7

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    Wuhan Vanz Pharm Inc. is a manufacturer&trading company.

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     China (Mainland)  |  Contact Details

    Business Type:Manufacturers

    Tel:86-27-84492310

    Address:FANHU INDUSTRY PARK

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    458-37-7

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    Ality Group, established in 2007, is a comprehensive Chemical Supply Group with Patent Technology as its core. Ality Group operates branches in Hong Kong, Singapore and mainland Ch

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:0513-87616220

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    458-37-7

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     China (Mainland)  |  Contact Details

    Business Type:Other

    Tel:+8615102730682

    Address:No.43, Xinandu Industrial Park, East and West Lake District, Wuhan, Hubei, China

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    458-37-7

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    Shaanxi Mingqi Chemical Co., Ltd is committed to the development of import and export trade in the production, operation and plant extracts of pharmaceutical raw materials and inte

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    Business Type:Lab/Research institutions

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    Welcome to Henan Tianfu Chemical Co., Ltd. Our company engages in noble metal catalysts, synthesis of electronic chemical materials and Pharmaceutical, Agrochemicals, Food Additive

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    Business Type:Lab/Research institutions

    Tel:86-371-55170693/55170694

    Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China

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    Business Type:Trading Company

    Tel:+86-13111626072

    Address:Room 1710, Baoxin International Phase I, 19 Guanyun East Road, Zhuozhou, Hebei

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    458-37-7

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     China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

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  • Curcumin/ LIDE PHARMA- Factory supply / Best price

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    458-37-7

    Curcumin/ LIDE PHARMA- Factory supply / Best price

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    FOB Price:  USD $ 0.0-0.0/

    Advantage : LIDE PHARMACEUTICALS LTD. is a mid-small manufacturing-type enterprise, engaged in pharmaceutical intermediates of R&D, custom-made and production, and also involving trading chemicals for export. We have established the R&

    LIDE PHARMACEUTICALS LIMITED is one of the fastest growing pharmaceutical company in China. We have developed strategic partnership with our manufacturing associates having state o

  •  LIDE PHARMACEUTICALS LIMITED

    China (Mainland)  |  Contact Details

    Business Type:Lab/Research institutions

    Tel:+86-25-58409506

    Address:11F, Building A1, No.288 North Zhongshan Road, Gulou District, Nanjing,210003, P.R.China.

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Consensus Reports

Reported in EPA TSCA Inventory.

Specification

The Curcumin, with the CAS registry number 458-37-7, is also known as 1,7-Bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione; C.I. 75300; C.I. Natural Yellow 3; Diferuloylmethane. It belongs to the product categories of Colorants;Natural Plant Extract;Aromatics;Pharmaceuticals.This chemical's molecular formula is C21H20O6 and molecular weight is 368.38.Its EINECS number is 207-280-5. What's more,Its systematic name is Curcumin.It is orange crystalline powder,Stable,but may be light sensitive,Incompatible with strong oxidizing agents,Slightly soluble in hot water.Curcumin is sensitive to light and changes in pH,and may react with oxidizing materials.

Physical properties about Curcumin are:
(1)ACD/LogP: 3.071; (2)# of Rule of 5 Violations: 0; (3)ACD/LogD (pH 5.5): 3.07; (4)ACD/LogD (pH 7.4): 2.96; (5)ACD/BCF (pH 5.5): 126.55; (6)ACD/BCF (pH 7.4): 98.45; (7)ACD/KOC (pH 5.5): 1111.61; (8)ACD/KOC (pH 7.4): 864.84; (9)#H bond acceptors: 6; (10)#H bond donors: 2; (11)#Freely Rotating Bonds: 10; (12)Index of Refraction: 1.643; (13)Molar Refractivity: 104.048 cm3 ; (14)Molar Volume: 287.893 cm3; (15)Surface Tension: 54.3230018615723 dyne/cm; (16)Density: 1.28 g/cm3; (17)Flash Point: 208.941 °C; (18)Enthalpy of Vaporization: 91.47 kJ/mol; (19)Boiling Point: 591.364 °C at 760 mmHg; (20)Vapour Pressure: 0 mmHg at 25°C.

Uses of Curcumin:
The Curcumin is brightly colored and may be used as a food coloring. It has been used historically as a component of Indian Ayurvedic medicine since 1900 BCE to treat a wide variety of ailments.It is obtained from tumeric, the powdered root of curcuma longa. It is used in the preparation of curcuma paper and the detection of boron. Curcumin appears to possess a spectrum of pharmacological properties, due primarily to its inhibitory effects on metabolic enzymes.It is a natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.

You can still convert the following datas into molecular structure:
(1)SMILES:O=C(\C=C\c1ccc(O)c(OC)c1)CC(=O)\C=C\c2cc(OC)c(O)cc2;
(2)Std. InChI:InChI=1S/C21H20O6/c1-26-20-11-14(5-9-18(20)24)3-7-16(22)13-17(23)8-4-15-6-10-19(25)21(12-15)27-2/h3-12,24-25H,13H2,1-2H3/b7-3+,8-4+;
(3)Std. InChIKey:VFLDPWHFBUODDF-FCXRPNKRSA-N;

The toxicity data of Curcumin as follows:

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1500mg/kg (1500mg/kg)   Indian Journal of Medical Research. Vol. 64, Pg. 601, 1976.
mouse LD50 oral > 2gm/kg (2000mg/kg)   Journal of Pharmacy and Pharmacology. Vol. 25, Pg. 447, 1973.
rat LD oral > 2gm/kg (2000mg/kg)   Planta Medica. Vol. 64, Pg. 353, 1998.