Solid phase synthesis of chiral 3-substituted quinazoline-2,4-diones

Article abstract of DOI:10.1016/0040-4039(96)01541-9

The synthesis of chiral 3-substituted quinazoline-2,4-diones was performed starting from N-urethane anthranilamides. This synthetic pathway was applied in solid phase, from commercially available anthranilic acid that was bound to hydroxymethyl polystyrene resin via a carbamate linker. In both cases, cyclisation occurred under basic conditions to afford non-racemized quinazolinediones in high purity.