Pyrrole butyric acid derivatives as inhibitors of steroid 5α- reductase

DOI: 10.1248/cpb.45.1767

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1767 - 1776 (1997)

Update date:2022-08-05

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Authors:

Kato, Masaya

Komoda, Keiko

Namera, Akira

Sarai, Yusuke

Okada, Satoshi

Yamada, Akira

Yokoyama, Kouichi

Migita, Emiko

Minobe, Yasushi

Tani, Tadato

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Article abstract of DOI:10.1248/cpb.45.1767

A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.

Full text of DOI:10.1248/cpb.45.1767

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