Chemical and Pharmaceutical Bulletin p. 1767 - 1776 (1997)
Update date:2022-08-05
Topics:
Kato, Masaya
Komoda, Keiko
Namera, Akira
Sarai, Yusuke
Okada, Satoshi
Yamada, Akira
Yokoyama, Kouichi
Migita, Emiko
Minobe, Yasushi
Tani, Tadato
A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.
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