Pyrrole butyric acid derivatives as inhibitors of steroid 5α- reductase

DOI: 10.1248/cpb.45.1767

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1767 - 1776 (1997)

Update date:2022-08-05

Topics:

Authors:

Kato, Masaya

Komoda, Keiko

Namera, Akira

Sarai, Yusuke

Okada, Satoshi

Yamada, Akira

Yokoyama, Kouichi

Migita, Emiko

Minobe, Yasushi

Tani, Tadato

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.45.1767

A series of pyrrole butyric acid derivatives was synthesized and evaluated for inhibitory activity on human and rat steroid 5α-reductase in vitro and ex vivo. 3-Benzoyl-4-alkylpyrrole-1-butyric acids and 1-methyl- 2-alkyl-3-benzoylpyrrole-5-butyric acid derivatives were effective inhibitors. Structure activity relationships were evaluated among the 37 compounds synthesized. Compound 37 (HQL-1069) shows potent inhibitory activities against both rat and human 5α-reductase.

Full text of DOI:10.1248/cpb.45.1767

NII-Electronic Library Service

Products guided by the article

Product name:5-Ethyl-4-(3-nitro-benzoyl)-1H-pyrrole-2-carbaldehyde

Cas No:199995-80-7

R&D Labs maybe for 199995-80-7

Penglai Qianwei Chemical Co., Ltd.

Contact:86-535-3357802

Address:Shahelu (north), Penglai, Shandong, China
ZHEJIANG JIANYE CHEMICAL CO.,LTD.

Contact:86-571-64149273,64149234

Address:No. 48, Fuxi Road, Meicheng Town
SICHUAN TONGSHENG AMINOACID CO.LTD

website:http://www.aminoacid.cc

Contact:86-838-2274206/2850606

Address:Room 1-11-1,No.19 of North TianShan Road,Deyang,Sichuan China
Zhejiang Sucon Silicone Co.,Ltd

Contact:+86-575-88046692

Address:Qisheng Rd., Paojiang Industrial Zone, Shaoxing, Zhejiang, China.
Shreeji pharma international

Contact:0091-265-2313036

Address:311, ATLANTIS HEIGHTS SARABHAI MAIN ROAD,VADIWADI ,VADODARA

Relevant to this article

Stereoselective synthesis of (R)- and (S)-2-methyl-3-oxo-3,4-dihydro- 2H-1,4-benzoxazine-2-carboxylic acids, -carboxylates and -carboxamides

Doi:10.1016/S0957-4166(98)00485-6
(1999)
Doi:10.1021/jm00293a004
(1971)
Reaction of 1-substituted 2-piperidones with phosphoryl chloride. IV. Interconversion of the beta-keto-amide and the quaternary salt

Doi:10.1248/yakushi1947.89.8_1045
(1969)
Sterically demanding cyclopentadienyl chemistry: Synthesis of iron and zirconium complexes of 1-phenyl-3-methyl-4,5,6,7-tetrahydroindenyl

Doi:10.1016/S0022-328X(99)00446-5
(1999)
Dihydroisoquinoline-rearrangement. 10. Mechanism of rearrangement of tertiary 1,2-dihydroisoquinolines

Doi:10.1002/ardp.19703030106
(1970)
Doi:10.1139/v70-135
(1970)

Article Doi