Bioorganic and Medicinal Chemistry Letters p. 3081 - 3084 (1997)
Update date:2022-09-26
Topics:
Hutchinson, Sally A.
Luetjens, Henning
Scammells, Peter J.
5-(3-Hydroxypropyl)-7-methoxy-2-(3'-methoxy-4'-hydroxyphenyl)benzo[b]furan-3 -carbaldehyde (XH-14, 1) has been reported to be a potent A1 adenosine antagonist. We have developed an efficient synthesis of this compound that should prove valuable for further structure-activity studies. The synthesis incorporates optimised methodology for the selective protection of a hydroxyl group and the ortho-bromination of a phenol.
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