Design and synthesis of a water-soluble taxol analogue: Taxol-sialyl conjugate

DOI: 10.1016/S0960-894X(97)10189-5

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 113 - 116 (1998)

Update date:2022-09-26

Topics:

Authors:

Takahashi, Takashi

Tsukamoto, Hirokazu

Yamada, Haruo

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Article abstract of DOI:10.1016/S0960-894X(97)10189-5

Glycosidation, using the methylthio derivative of N-acetylneuraminic acid 3, of linker alcohol 4 in DME with 'long-range participation' produced the α-glycosyl linkage with high stereoselectivity. The α-linked sialic acid 2 was introduced in taxol without protection of the alcohol functionality in sialic acid.

Full text of DOI:10.1016/S0960-894X(97)10189-5

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