Synthesis of enantiomerically pure, all syn, tetra and pentasubstituted cyclopentanes by the desymmetrisation of endo-norborn-5-ene-2,3-dicarboxylic anhydrides

Article abstract of DOI:10.1055/s-1997-1060

Ozonolysis of diastereomerically pure norbornene derivatives incorporating methyl (S)-prolinate provides a route for the synthesis of enantiomerically pure cyclopentanes bearing four or five substituents all orientated syn to one another.