
Journal of Medicinal Chemistry p. 1958 - 1968 (2000)
Update date:2022-07-30
Topics:
Pedregal, Concepción
Collado, Iván
Escribano, Ana
Ezquerra, Jesús
Dominguez, Carmen
Mateo, Ana I.
Rubio, Almudena
Baker, S. Richard
Goldsworthy, John
Kamboj, Rajender K.
Ballyk, Barbara A.
Hoo, Ken
Bleakman, David
Enantiomerically pure (2S,4R)-4-substituted glutamic acids were prepared and tested for homomeric GluR5 and GluR6 kainate subtype receptor affinity. Some of the 4-cinnamyl analogues showed high selectivity and potency (K(i) < 25 nM) for the GluR5 receptor
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