Bioorganic and medicinal chemistry letters p. 235 - 238 (2001)
Update date:2022-08-03
Topics:
Levin
Du
DiJoseph
Killar
Sung
Walter
Sharr
Roth
Moy
Powers
Jin
Cowling
Skotnicki
A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, and MMP-13 was prepared and evaluated both in vitro and in vivo. The most potent compound, 6e, has in vivo activity in a rat sponge-wrapped cartilage model.
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