A synthesis of (+)-9a-desmethoxymitomycin A via aziridinyl radical cyclization

Article abstract of DOI:10.1016/S0040-4039(98)00286-X

A synthesis of (+)-desmethoxymitomycin A is described. The critical step is a highly stereoselective cyclization of an aziridinyl radical to afford a tetracycle having the same relative and absolute stereochemistry as mitomycin A and C.