The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1' residues

DOI: 10.1016/S0960-894X(98)00119-X

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 823 - 828 (1998)

Update date:2022-09-26

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Authors:

Patel, Mona

Bacheler, Lee T.

Rayner, Marlene M.

Cordova, Beverly C.

Klabe, Ronald M.

Erickson-Viitanen, Susan

Seitz, Steven P.

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Article abstract of DOI:10.1016/S0960-894X(98)00119-X

Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP450.

Full text of DOI:10.1016/S0960-894X(98)00119-X

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