Bioorganic and Medicinal Chemistry Letters p. 823 - 828 (1998)
Update date:2022-09-26
Topics:
Patel, Mona
Bacheler, Lee T.
Rayner, Marlene M.
Cordova, Beverly C.
Klabe, Ronald M.
Erickson-Viitanen, Susan
Seitz, Steven P.
Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP450.
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Doi:10.1080/00945719809351668
(1998)Doi:10.1016/S0968-0896(02)00127-X
(2002)Doi:10.1021/jo701900k
(2007)Doi:10.1016/S0957-4166(98)00087-1
(1998)Doi:10.1002/jhet.5570320532
(1995)Doi:10.1021/ja973464e
(1998)
