The synthesis and evaluation of cyclic ureas as HIV protease inhibitors: Modifications of the P1/P1' residues

Article abstract of DOI:10.1016/S0960-894X(98)00119-X

Two series of cyclic ureas modified at the P1/P1' residue were prepared and evaluated for HIV protease inhibition and whole cell antiviral activity. Compounds 8b, 10 (3- and 4-pyridylmethyl analogs) and 6b (4-methoxy analog) showed significant improvement in antiviral activity relative to lead compounds DMP323 and DMP450.