Tetrahedron Letters p. 5233 - 5236 (1998)
Update date:2022-07-29
Topics:
Sakai, Takashi
Miki, Yasushi
Nakatani, Mayumi
Ema, Tadashi
Uneyama, Kenji
Utaka, Masanori
The lipase-catalyzed kinetic resolution of (±)-2-acyloxy-2- (pentafluorophenyl)acetonitrile (±)-1 gave optically active cyanohydrin (S)- 2 and its antipodal ester (R)-1 (E = 211), the former of which was transformed (TBSOTf, DMAP) into its TBS-ether (S)-3, a new fluorinated chiral building block, and into naproxen ester 4 for X-ray analysis to determine the absolute configuration.
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Doi:10.1021/jo01263a030
(1969)Doi:10.1016/S0960-894X(98)00318-7
(1998)Doi:10.1021/jo980234p
(1998)Doi:10.1002/hlca.19980810556
(1998)Doi:10.1021/om980283s
(1998)Doi:10.1016/S0960-894X(98)00382-5
(1998)
