Solution and solid phase combinatorial synthesis of peptidomimetic library containing diversified α-methylated amino acids

DOI: 10.1016/S0960-894X(98)00279-0

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1665 - 1668 (1998)

Update date:2022-08-05

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Authors:

Kim, Sang Woong

Shin, You Seung

Ro, Seonggu

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Article abstract of DOI:10.1016/S0960-894X(98)00279-0

A combinatorial peptidomimetic library containing diversified α- methylated amino acids was generated by the Ugi four component condensation (4cc) reaction from acids, amines, isocyanides and ketones in both solution and solid phase synthesis procedures. This one-pot methodology overall gave fair to good yields, which compare well with multi-step syntheses.

Full text of DOI:10.1016/S0960-894X(98)00279-0

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