Resolution, In vitro and In vivo evaluation of fluorine-18-labeled isomers of 1-azabicyclo[2.2.2]oct-3-yl α-(1-fluoropent-5-yl)-α-hydroxy-α- phenylacetate (FQNPe) as new PET candidates for the imaging of muscarinic- cholinergic receptor

Article abstract of DOI:10.1002/(SICI)1099-1344(1998080)41:8<681::AID-JLCR131>3.0.CO;2-Q

1-Azabicyclo[2.2.2]oct-3-yl α-(1-fluoropent-5-yl)-α-hydroxy-α- phenylacetate (FQNPe, 2), an analogue of 1-azabicyclo[2.2.2]oct-3-yl α,α- (diphenyl)-α-hydroxyacetate (QNB), was resolved into its four stereoisomers. In vitro binding assays of the stereoisom