Synthesis and biological activities of topoisomerase I inhibitors, 6-arylmethylamino analogues of edotecarin

DOI: 10.1021/jm801641t

Source and publish data:

Journal of Medicinal Chemistry p. 3225 - 3237 (2009)

Update date:2022-07-30

Topics:

Authors:

Sunami, Satoshi

Nishimura, Teruyuki

Nishimura, Ikuko

Ito, Satoru

Arakawa, Hiroharu

Ohkubo, Mitsuru

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Article abstract of DOI:10.1021/jm801641t

The replacement of 1,3-dihydroxy-2-propylamino moiety at the N6-position of edotecarin (1) by arylmethylamino groups yielded a number of more potent topoisomerase I inhibitors with better cytotoxic (CTX) activities in vitro than edotecarin. Among them, th

Full text of DOI:10.1021/jm801641t

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