Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

DOI: 10.1016/S0040-4039(98)01361-6

Source and publish data:

Tetrahedron Letters p. 6543 - 6546 (1998)

Update date:2022-07-30

Topics:

Authors:

Esposito, Annamaria

Falorni, Massimo

Taddei, Maurizio

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Article abstract of DOI:10.1016/S0040-4039(98)01361-6

Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis- azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.

Full text of DOI:10.1016/S0040-4039(98)01361-6

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