Synthesis of amphiphilic polyhydroxylated pyrrolidines as potential glycosidase inhibitors

Article abstract of DOI:10.1016/S0040-4039(98)01361-6

Several polyhydroxylated pyrrolidines with an aliphatic long chain on the ring nitrogen were prepared starting from D-mannitol. An amphiphilic bis- azasugar scaffold has been also prepared. These products behave as cationic surfactants and show a promising anti HIV-1 activity.