New prodrugs of 9-(2-phosphonomethoxyethyl) adenine [PMEA]: Synthesis and stability studies

Article abstract of DOI:10.1080/15257779508012428

The synthesis, and stability in different media of new PMEA prodrugs, with S-acyl-thioethyl (SATE) as enzyme-labile phosphonate protecting groups, are described in comparison with the already known Bis(POM)- and Bis(DTE)PMEA.

Full text of DOI:10.1080/15257779508012428

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Nucleosides and Nucleotides
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New Prodrugs of 9-(2-
Phosphonomethoxyethyl)adenine
[PMEA]: Synthesis and Stability Studies
S. Benzaria a , G. Gosselin a , H. Pelicano a , G. Maury a , A.-M.
Aubertin b , G. Obert b , A. Kirn b & J.-L. Imbach a
a Laboratoire de Chimie Bio-Organique, U. R. A 488 CNRS ,
Universitéa de Montpellier II , 34095, Montpellier Céadex, 5
b Universitéa Louis Pasteur , INSERM U 74, 67000, Strasbourg,
(France)
Published online: 16 Feb 2007.
To cite this article: S. Benzaria , G. Gosselin , H. Pelicano , G. Maury , A.-M. Aubertin , G. Obert , A.
Kirn & J.-L. Imbach (1995) New Prodrugs of 9-(2-Phosphonomethoxyethyl)adenine [PMEA]: Synthesis
and Stability Studies, Nucleosides and Nucleotides, 14:3-5, 563-565
To link to this article: http://dx.doi.org/10.1080/15257779508012428
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