Binreduction of (R)-carvone and regioselective baeyer-villiger oxidations: Application to the asymmetric synthesis of cryptophycin fragment A

Article abstract of DOI:10.1016/S0040-4039(98)01784-5

Cryptophycin fragment A (1) was prepared in high enantiomeric purity in 10 steps from (R)-carvone. A stereoselective bioreduction of (R)-carvone to neodihydrocarveol and a regioselective Baeyer-Villiger oxidation of cyclohexanone 8 with pertrifluoroacetic acid were employed in this synthesis.