Orthoester-condensation/C-O insertion reaction sequence for the preparation of tetrahydrofurans

DOI: 10.1016/S0040-4039(98)01987-X

Source and publish data:

Tetrahedron Letters p. 8813 - 8816 (1998)

Update date:2022-08-04

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Authors:

Calter, Michael A.

Sugathapala, Priyantha M.

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Article abstract of DOI:10.1016/S0040-4039(98)01987-X

This paper describes a general procedure for the efficient preparation of highly substituted tetrahydrofurans. The condensation of α-diazo-β- ketoester-derived enolates with orthoesters yields diazoacetals 1a-1d. These compounds undergo formal C-O inserti

Full text of DOI:10.1016/S0040-4039(98)01987-X

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