Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1,4] benzodiazepine and minor-groove-binding oligopyrrole carriers

DOI: 10.1021/jm991033w

Source and publish data:

Journal of Medicinal Chemistry p. 5131 - 5141 (1999)

Update date:2022-08-05

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Authors:

Baraldi, Pier Giovanni

Balboni, Gianfranco

Cacciari, Barbara

Guiotto, Andrea

Manfredini, Stefano

Romagnoli, Romeo

Spalluto, Giampiero

Thurston, David E.

Howard, Philip W.

Bianchi, Nicoletta

Rutigliano, Cristina

Mischiati, Carlo

Gambari, Roberto

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Article abstract of DOI:10.1021/jm991033w

The synthesis, biological activity, and DNA-binding properties of a series of four hybrids prepared by combining polypyrrole minor groove binders and pyrrolo[2,1-c][1,4]benzodiazepine (PBD) 13, related to the naturally occurring anthramycin (3) and DC-81

Full text of DOI:10.1021/jm991033w

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