Novel phosphate mimetics for the design of non-peptidyl inhibitors of protein tyrosine phosphatases

Article abstract of DOI:10.1016/S0960-894X(98)00598-8

Benzylic α,α-difluorosulfonates, α,α-difluorotetrazoles, and α,α- difluorocarboxylates of type 5 and 6 were synthesized and examined as potential phosphate biosteres for PTP1B inhibition. The α,α- difluorosulfonates and α,α-difluorotetrazoles were found t