Synthesis of (2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine from (4S,5S)-3-benzyl-4-formyl-5-vinyl-2-oxazolidinone

DOI: 10.3987/com-98-8292

Source and publish data:

Heterocycles p. 2263 - 2278 (1998)

Update date:2022-08-04

Topics:

Authors:

Wee, Andrew G. H.

McLeod, Douglas D.

Rankin, Trent J.

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Article abstract of DOI:10.3987/com-98-8292

(4S,5S)-3-BenzyI-4-formyl-5-vinyl-2-oxazolidinone (2), readily prepared via the reductive elimination of the mannose-derived iodo phenyl sulfone (6b), is used in the synthesis of the alkaloid (2R,3S)-3-hydroxy-2-hydroxymethylpyrrolidine (1).

Full text of DOI:10.3987/com-98-8292

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Product name:(3aS,4R,6R,6aS)-4-Benzenesulfonyl-6-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxole

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