Bioorganic and Medicinal Chemistry Letters p. 3525 - 3530 (1998)
Update date:2022-08-05
Topics:
Semple, J. Edward
Rowley, David C.
Owens, Timothy D.
Minami, Nathaniel K.
Uong, Theresa H.
Brunck, Terence K.
Crystal structure and evolving SAR considerations of potent, selective benzylsulfonamide lactam thrombin inhibitors and related serine protease inhibitors have led to the design of novel thrombin inhibitors lag, featuring hydrophobic, basic, P4-alkylaminolactam scaffolds that serve as novel types of P3-P4 dipeptide mimics. The design, synthesis, and biological activity of these targets is presented.
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Doi:10.1021/jo0106389
(2001)Doi:10.1016/S0040-4039(98)02383-1
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(1999)Doi:10.1016/S0957-4166(99)00287-6
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(1999)Doi:10.1246/bcsj.42.258
(1969)
