Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex

DOI: 10.1248/cpb.47.11

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 11 - 21 (1999)

Update date:2022-09-26

Topics:

Authors:

Okamoto, Yoshinori

Anan, Hideki

Nakai, Eiichi

Morihira, Koichiro

Yonetoku, Yasuhiro

Kurihara, Hiroyuki

Sakashita, Hitoshi

Terai, Yoshiya

Takeuchi, Makoto

Shibanuma, Tadao

Isomura, Yasuo

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Article abstract of DOI:10.1248/cpb.47.11

Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L- 709049) and interleukin-1β converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH₂OPh (1) to obtain a potent inhibitor in the cell

Full text of DOI:10.1248/cpb.47.11

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