Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex

DOI: 10.1248/cpb.47.11

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 11 - 21 (1999)

Update date:2022-09-26

Topics:

Authors:

Okamoto, Yoshinori

Anan, Hideki

Nakai, Eiichi

Morihira, Koichiro

Yonetoku, Yasuhiro

Kurihara, Hiroyuki

Sakashita, Hitoshi

Terai, Yoshiya

Takeuchi, Makoto

Shibanuma, Tadao

Isomura, Yasuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.11

Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L- 709049) and interleukin-1β converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH₂OPh (1) to obtain a potent inhibitor in the cell

Full text of DOI:10.1248/cpb.47.11

NII-Electronic Library Service

Products guided by the article

Product name:(3S,4RS)-3-<amino>-4-hydroxy-5-phenoxypentanoic acid tert-butyl ester

Cas No:221106-06-5

R&D Labs maybe for 221106-06-5

Hawks Chemical

Contact:+44 (0)161 367 9441

Address:
Shanggao Ruiya Fine Chemicals Co., Ltd

Contact:+86-795-2592103

Address:Xingguang Nanlu,Shanggao County Industry Park
Taixing Joxin Bio-tec Co.,Ltd.

website:http://www.joxbio.com

Contact:86-523-87558858 87612088

Address:No.88, chengdong industrial park
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Nanjing Habo Medical Technology Co., Ltd.

Contact:025－85769882

Address:No.108. Ganjiabian east. Qixia District .Nanjing

Relevant to this article

Use of β-Silylethyl Vinyl Ketone as a β-Hydroxyethyl Vinyl Ketone Synthon in the Robinson Annulation Reaction

Doi:10.1021/jo00052a068
(1992)
High-affinity inhibitors of dihydrofolate reductase: Antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size

Doi:10.1021/jm9505122
(1996)
Direct screening for phosphatase activity by turnover-based capture of protein catalysts.

Doi:10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F
(2002)
Oxidative Cleavage of Mono-, Di-, and Trisubstituted Olefins to Methyl Esters through Ozonolysis in Methanolic NaOH

Doi:10.1021/jo00066a019
(1993)
Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor α

Doi:10.1248/bpb.18.1228
(1995)
A water-soluble calix[4]arene-based podand incorporating 4,4′-dicarboxy-2,2′-bipyridine chelating units - Synthesis and complexation properties towards copper ions

Doi:10.1002/ejic.200300690
(2004)

Article Doi