Peptide based interleukin-1β converting enzyme (ICE) inhibitors: Synthesis, structure activity relationships and crystallographic study of the ICE-inhibitor complex

DOI: 10.1248/cpb.47.11

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 11 - 21 (1999)

Update date:2022-09-26

Topics:

Authors:

Okamoto, Yoshinori

Anan, Hideki

Nakai, Eiichi

Morihira, Koichiro

Yonetoku, Yasuhiro

Kurihara, Hiroyuki

Sakashita, Hitoshi

Terai, Yoshiya

Takeuchi, Makoto

Shibanuma, Tadao

Isomura, Yasuo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1248/cpb.47.11

Based on the X-ray structure of the complex of Ac-Tyr-Val-Ala-Asp-H (L- 709049) and interleukin-1β converting enzyme (ICE), we synthesized compounds which were derived from 2-NapCO-Val-Pro-Asp-CH₂OPh (1) to obtain a potent inhibitor in the cell

Full text of DOI:10.1248/cpb.47.11

NII-Electronic Library Service

Products guided by the article

Product name:(3S,4RS)-3-<amino>-4-hydroxy-5-phenoxypentanoic acid tert-butyl ester

Cas No:221106-06-5

R&D Labs maybe for 221106-06-5

VanderArk International Limited

Contact:86-10-82437576

Address:Qing He
Evershine Chemical CO Ltd

Contact:+86-571-87010026

Address:202, Zhenhua Road,
Aqua Chem Industry Co., Ltd

Contact:+86-515-88356562

Address:No.2, West Daqing Road, Yancheng, Jiangsu, China
ZHEJIANG PAULA INDUSTRY CO.,LTD

website:http://www.haiqiangchem.com

Contact:86-571-86960380

Address:6th floor, building 2, dongfangmao business center, Xiacheng District, Hangzhou City, Zhejiang Province
Henan Harvest Chem Co., Ltd

Contact:+86-371-86058576

Address:NO.32, Jingsan Road, Zhengzhou, China

Relevant to this article

Use of β-Silylethyl Vinyl Ketone as a β-Hydroxyethyl Vinyl Ketone Synthon in the Robinson Annulation Reaction

Doi:10.1021/jo00052a068
(1992)
High-affinity inhibitors of dihydrofolate reductase: Antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size

Doi:10.1021/jm9505122
(1996)
Direct screening for phosphatase activity by turnover-based capture of protein catalysts.

Doi:10.1002/1521-3773(20020301)41:5<775::AID-ANIE775>3.0.CO;2-F
(2002)
Oxidative Cleavage of Mono-, Di-, and Trisubstituted Olefins to Methyl Esters through Ozonolysis in Methanolic NaOH

Doi:10.1021/jo00066a019
(1993)
Benzylphthalimides and phenethylphthalimides with thalidomide-like activity on the production of tumor necrosis factor α

Doi:10.1248/bpb.18.1228
(1995)
A water-soluble calix[4]arene-based podand incorporating 4,4′-dicarboxy-2,2′-bipyridine chelating units - Synthesis and complexation properties towards copper ions

Doi:10.1002/ejic.200300690
(2004)

Article Doi