Tetrahedron Letters p. 483 - 486 (1999)
Update date:2022-07-30
Topics:
Bringmann, Gerhard
Pabst, Thomas
Rycroft, David S.
Connolly, Joseph D.
The first synthesis of mastigophorenes A and B by oxidative phenolic coupling of partially protected derivatives of their joint natural monomeric half, herbertenediol, is described. The synthesis starts from this diol itself or from the corresponding aldehyde, both available by isolation from the liverwort, Herbertus aduncus. After transformation of herbertenediol to a chemically appropriate monophenolic coupling precursor, the oxidative dehydrodimerization was brought about using (tert-BuO)2, followed by deprotection to give mastigophorenes A and B in their 'natural' atropisomeric ratio, as isolated from the liverwort.
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Doi:10.1016/S0040-4039(99)00006-4
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(2019)
