Synthesis of taxoids 4. Novel and versatile methods for preparation of new taxoids by employing cis- or trans-phenyl glycidic acid

DOI: 10.1016/S0040-4020(98)01108-9

Source and publish data:

Tetrahedron p. 1005 - 1016 (1999)

Update date:2022-08-03

Topics:

Authors:

Yamaguchi, Tetsuo

Harada, Naoyuki

Ozaki, Kunihiko

Hayashi, Masahito

Arakawa, Hiroaki

Hashiyama, Tomiki

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Article abstract of DOI:10.1016/S0040-4020(98)01108-9

A novel route to the synthesis of docetaxel using esterification of (2R,3R)-or (2R,3S)-glycidic acid with 7,10-bis-O-(2,2,2- trichloroethoxycarbonyl)-10-deacetylbaccatin III is described. Related novel taxoids which have new side chains were synthesized from these synthetic intermediates.

Full text of DOI:10.1016/S0040-4020(98)01108-9

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