Bioorganic and Medicinal Chemistry Letters p. 539 - 542 (1999)
Update date:2022-08-04
Topics:
Pei, Xue-Feng
Sturgess, Michael A.
Fernando Valenzuela
Maccecchini, Maria-Luisa
Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.
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