Bioorganic and Medicinal Chemistry Letters p. 539 - 542 (1999)
Update date:2022-08-04
Topics:
Pei, Xue-Feng
Sturgess, Michael A.
Fernando Valenzuela
Maccecchini, Maria-Luisa
Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.
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Doi:10.1139/v65-015
(1965)Doi:10.1021/om980913q
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(1969)Doi:10.1248/cpb.56.1126
(2008)Doi:10.3390/molecules24020372
(2019)Doi:10.1021/acs.oprd.9b00048
(2019)
