Allosteric modulators of the AMPA receptor: Novel 6-substituted dihydrophthalazines

Article abstract of DOI:10.1016/S0960-894X(99)00044-X

Novel analogs of the allosteric AMPA receptor modulator SYM 2206 have been prepared. Structure/activity correlations of these novel analogs and other dihydrophthalazines (DHPs) reveal the important contribution of the heteroatom-based aryl substituents in this class of noncompetitive inhibitors. One of the analogs (6, SYM 2189) is equipotent with the early series, but with reduced sedation.