Journal of Heterocyclic Chemistry p. 141 - 144 (1999)
Update date:2022-07-30
Topics:
Hradil, Pavel
Hlavac, Jan
Lemr, Karel
Synthesis of 1,2-disubstituted-3-hydroxy-4(1H)-quinolinones by the cyclization of N-substituted phenacyl or acetonyl anthranilates is described. Two methods were employed for cyclization of anthranilates. Heating in polyphosphoric acid has a wide scope of applicability. The thermal cyclization in boiling N-methylpyrrolidone is limited by steric effect.
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