Synthesis of enantiopure 3-alkyl-perhydroazepines by diastereoselective 7-endo-radical cyclisation on a chiral 1,3-perhydrobenzoxazine derivative

Article abstract of DOI:10.1016/S0040-4039(99)00119-7

Competitive alkyl radical 6-exo/7-endo cyclisation on α,β-unsaturated amides derived from chiral perhydrobenzoxazines are controlled by the alkene substitution pattern. Stereocontrol leading to 7-endo regioisomers is considerably higher an allows to prepa