Mechanistic Change from (ElcB)R to (ElcB)i Brought about by a Sterically Bulky Substituent in Ester Hydrolysis

DOI: 10.1021/jo00357a001

Source and publish data:

Journal of Organic Chemistry p. 959 - 963 (1986)

Update date:2022-07-30

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Authors:

Inoue, Massachi

Bruice, Thomas C.

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Article abstract of DOI:10.1021/jo00357a001

The anticipated pH dependence of log k_rate for ElcB ester hydrolysis reactions is discussed.Rate constants for carbon acid ionization and reprotonation with a series of α-cyano esters have been determined over a limited pH range.The pH dependen

Full text of DOI:10.1021/jo00357a001

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