α-chlorination of ketones using p-toluenesulfonyl chloride

DOI: 10.1016/S0040-4039(99)00213-0

Source and publish data:

Tetrahedron Letters p. 2231 - 2234 (1999)

Update date:2022-07-30

Topics:

Authors:

Brummond, Kay M.

Gesenberg, Kirsten D.

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Article abstract of DOI:10.1016/S0040-4039(99)00213-0

Treatment of a variety of ketones with lithium diisopropylamide followed by p-toluenesulfonyl chloride gives α-chloroketones in good yields. In addition, a polymer bound tosyl chloride reagent has also been shown to effect this transformation.

Full text of DOI:10.1016/S0040-4039(99)00213-0

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