Bioorganic and Medicinal Chemistry Letters p. 1179 - 1184 (1999)
Update date:2022-08-03
Topics:
Kurihara, Shinwa
Tsumuraya, Takeshi
Fujii, Ikuo
Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.
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(2021)
