Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

DOI: 10.1016/S0960-894X(99)00154-7

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1179 - 1184 (1999)

Update date:2022-08-03

Topics:

Authors:

Kurihara, Shinwa

Tsumuraya, Takeshi

Fujii, Ikuo

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Article abstract of DOI:10.1016/S0960-894X(99)00154-7

Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.

Full text of DOI:10.1016/S0960-894X(99)00154-7

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