Structure-based design of diaminopyranosides as a novel inhibitor core unit of HIV proteases

Article abstract of DOI:10.1016/S0960-894X(99)00154-7

Novel HIV PR inhibitors, which contain a diaminopyranoside moiety as an inhibitor core unit, were designed based on the 3D structures of complexes of HIV-1 PR with transition-state mimics. These compounds were examined for their ability to inhibit the hydrolytic activity of a recombinant HIV-1 PR.