European Journal of Organic Chemistry p. 3622 - 3631 (2019)
Update date:2022-08-04
Topics:
Zheng, Changping
Bavaro, Teodora
Tengattini, Sara
Mascherpa, Andrea Gualla
Sollogoub, Matthieu
Zhang, Yongmin
Terreni, Marco
Highly regioselective deprotection of a series of 2-amino pyranose building blocks was achieved by enzymatic hydrolysis. These monodeprotected intermediates were successfully used in the synthesis of a variety of glycoconjugate derivatives with a core of glucosamine or galactosamine, including neo-glycoproteins and glycosphingolipids. The hydrolysis catalyzed by acetylxylan esterase from Bacillus pumilus (AXE) is suitable for the synthesis of neo-glycoproteins with an N-acetyl glucosamine core. The hydrolysis catalyzed by Candida rugosa lipase (CRL) was successfully applied in the preparation of new sialylated glycolipids starting from glucosamine building blocks protected as phthalimide. This chemoenzymatic approach can be used for the preparation of new glycoconjugate products with anticancer activity.
View MoreShanghai shibo Chemical Co., Ltd
Contact:+86-021-60753516
Address:688 Qiushi Road, Jinshan High-tech Park, Shanghai, China,201512
website:http://www.sdowchem.com
Contact:86-135-2193 7483
Address:8-106 taiyue building
Contact:021
Address:Pudong
NINGBO PANGS CHEM INT’L CO.,LTD.
Contact:+86-574-27666845
Address:FLOOR 21,BUILDING NO.11,XIN TIAN DI,NO.689 SHI JI ROAD,NINGBO CHINA
Zhonghao (dalian) Research and Design Institute of Chemical Industry Co., Ltd
Contact:+86 411 84674606
Address:201, Huangpu Road , Shahekou District, Dalian ,116023-China
Doi:10.1016/j.ijpharm.2018.05.056
(2018)Doi:10.1021/acs.jmedchem.6b01645
(2017)Doi:10.1055/s-1999-3442
(1999)Doi:10.1023/A:1013722518076
(2001)Doi:10.1016/S0040-4039(01)91151-7
(1984)Doi:10.1039/b803283a
(2008)