Tetrahedron p. 2927 - 2936 (1999)
Update date:2022-08-03
Topics:
Chiba, Akira
Eguchi, Tadashi
Oshima, Tairo
Kakinuma, Katsumi
A cyclopropane substrate analog 1 was designed as a mechanism-based inhibitor for 3-isopropylmalate dehydrogenase (IPMDH), the rate-determining enzyme responsible for the penultimate step in the biosynthetic pathway of the essential amino acid L-leucine.
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(1999)Doi:10.1021/om981021t
(1999)Doi:10.1039/c5ob00915d
(2015)Doi:10.1021/jo01025a016
(1964)Doi:10.1016/j.tetlet.2014.03.043
(2014)
